Designing A Non-Invasive Testing Device for Infant Diabetes using Saliva
Abstract
Neonatal diabetes is estimated to affect 1 in every 95,000 to 1 in every 400,000 live births. Male and female infants are equally affected by the disease, which has been recorded in all ethnic groups. Neonatal diabetes mellitus is a type of diabetes that develops within the first six months of life. Insulin is a hormone that aids in the production of energy in our cells. This condition causes infants to produce insufficient insulin, resulting in elevated blood glucose levels. Therefore, it is very important to design a testing device that can monitor premature babies indicating symptoms of diabetes. Recognizing the signs of diabetes in an infant might be difficult because diabetes in babies is not common. Frequent wet diapers, a high appetite, dehydration, and weight loss are all signs of neonatal diabetes. Once you have diabetes, you're used to having to take tests to monitor your condition. Conventionally invasive methods are used to check neonatal diabetes which is a painful procedure for infants as it requires prinking to draw blood several times per day. Therefore, this paper aims to design a non-invasive testing design for neonatal diabetes that is not painful to babies. There are several non-invasive ways to test blood glucose levels; urine, sweat, and saliva. Urine tests can be used to detect glucose levels in urine and check for the presence of ketones. The presence of ketone above the threshold indicates a high blood glucose level of over 300ml/dL. Sweat is also used to test diabetes. Hyperhidrosis (excessive sweating) is caused by high blood sugar levels, and it indicates that blood sugar control has to be tightened. Saliva is a new medium to measure blood glucose levels and research is going on its use to measure diabetes. Previous research has found a strong relationship between blood glucose levels and saliva glucose levels. In this paper, saliva is used as a non-invasive method to measure neonatal diabetes. Saliva containing glucose is collected and treated with glucose oxidase. H2O2 produced during this reaction is further treated and an optical sensor along with a microcontroller is used to measure the concentration of blood glucose. The expected results based on the study indicate the amount of glucose in the saliva increases in proportion to the amount of glucose in the blood and confirms the relationship between glucose concentrations in the blood and saliva, implying that the proposed design can take the place of the existing devices. However, more tests should be carried out to improve the efficacy of the proposed design for detecting glucose in saliva.
Copyright (c) 2022 Pakistan Journal of Engineering and Technology
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
COPYRIGHT POLICY
UOL journals follow an open-access publishing policy and full text of all articles is available free, immediately upon acceptance. Articles are published and distributed under the terms of the CC BY-SA 4.0 International License. Thus, work submitted to UOL Journals implies that it is original, unpublished work of the authors; neither published previously nor accepted/under consideration for publication elsewhere.
Authors will be responsible for any information written/informed/reported in the submitted manuscript. Although we do not require authors to submit the data collection documents and coded sheets used to do quantitative or qualitative analysis, we may request it at any time during the publication process, including after the article has been published. It is author's responsibility to obtain signed permission from the copyright holder to use and reproduce text, illustrations, tables, etc., published previously in other journals, electronic or print media.
Conflict of interest statements will be published at the end of the article. If no conflict of interest exists, the following sentence will be used: "The authors declare no conflict of interest." Authors are required to disclose any sponsorship or funding received from any institution relating to their research. The editor(s) will determine what disclosures, if any, should be available to the readers.
Authors are not permitted to post the work on any website/blog/forum/board or at any other place, by any means, from the time such work is submitted to UOL journals until the final decision on the paper has been given to them. In case a paper is accepted for publication, the authors may not post the work in its entirety on any website/blog/forum/board or at any other place, by any means, till the paper is published in UOL Journals.
The authors may, however, post the title, authors’ names and their affiliations and abstract, with the following statement on the first page of the paper - "The manuscript has been accepted for publication in UOL Journals". After publication of the article, it may be posted anywhere with full journal citation included.
All articles published in UOL journals are open-access articles, published and distributed under the terms of the Creative Commons Attribution-ShareAlike 4.0 International License which permits remixing, transformation, or building upon the material, provided the original work is appropriately cited mentioning the authors and the publisher, as well as the produced work is distributed under the same license as the original.
In the future, UOL may reproduce printed copies of articles in any form. Without prejudice to the terms of the license given below, we retain the right to reproduce author's articles in this way.
Brief Summary Of The License Agreement
By submitting your research article(s) to UOL Journal(s), you agree to Creative Commons Attribution-ShareAlike 4.0 International License which states that:
Anyone is free:
o To copy and redistribute the material in any medium or format
o To remix, transform, or build upon the material for any purpose, even commercially
Provided:
o The author and the publisher have been appropriately credited
o The link to license is provided
o Indicated if any changes were made
o The material produced is distributed under the same license as the original