GLYCOSYLATED HEMOGLOBIN HBA1C AS A MARKER OF GLYCEMIC STATUS AND DYSLIPIDEMIA IN DIABETES MELLITUS

Hba1c as a Marker of Glycemic Status and Dyslipidemia

Abstract

Diabetes mellitus is a group of metabolic disorders that cause hyperglycemia due to underutilization or e x c e ssi v e g l u c o s e a c c umu l a ti o n . Li p i d , carbohydrates and protein metabolism abnormalities
occur due to insulin dysfunction. Glycated hemoglobin (HbA1c) is a routinely used marker for long-term glycemic control.

OBJECTIVE: To test HbA1c as a diagnostic parameter of blood lipids among diabetic patients to determine the effects of good glycemic control on lipid profile of individuals having DM.
METHODS: 267 diabetic patients of both gender were included in the study. Two groups were made on the basis of their glycemic status. HbA1c, triglycerides, total cholesterol, HDL high density lipoprotein, LDL low
density lipoprotein and VLDL were measured in both
groups.
RESULTS: Worst glycemic control group showed statistically significant higher levels of triglycerides, cholesterol, very low density lipoprotein and inverse levels of high density lipoprotein cholesterol when compared to good glycemic control group.
CONCLUSIONS: It was concluded that HbA1c and lipid profile parameters especially triglycerides, cholesterol and very low density lipoprotein cholesterol were
positively correlated with both glycemic control
groups irrespective of the gender.