THE EFFECTS OF SOME MEDICINAL PLANTS (FOUND IN SOUTHWEST NIGERIA) ON SEX HORMONES IN MALE WISTAR RATS

Some Medicinal plants and sex hormones in male Wistar rats

  • Ifabunmi Oduyemi Osonuga Department of Physiology, Faculty of Basic Medical Sciences, Olabisi Onabanjo University, Sagamu Campus, Sagamu, Ogun State, Nigeria
  • Baliqis Adejoke Olukade Department of Physiology, Faculty of Basic Medical Sciences, Olabisi Onabanjo University, Sagamu Campus, Sagamu, Ogun State, Nigeria
  • Albert Abiodun Ogunlade Department of Physiology, Faculty of Basic Medical Sciences, Olabisi Onabanjo University, Sagamu Campus, Sagamu, Ogun State, Nigeria
  • Victoria Biola Edema Department of Physiology, Faculty of Basic Medical Sciences, Olabisi Onabanjo University, Sagamu Campus, Sagamu, Ogun State, Nigeria
  • Oyinlolaoluwa Oluwadolapo Osonuga Department of Pharmacology, Faculty of Basic Medical Sciences, Olabisi Onabanjo University, Sagamu Campus, Sagamu, Ogun State, Nigeria
  • Babatunde Olufemi Okebule Department of Physiology, Faculty of Basic Medical Sciences, Olabisi Onabanjo University, Sagamu Campus, Sagamu, Ogun State, Nigeria
  • Patrick Godwin Okwute Department of Physiology, School of Basic Medical Sciences, Babcock University, Ilishan-Remo, Ogun State, Nigeria
DOI: https://doi.org/10.52229/ajahs.v8i1.2391

Abstract

Objectives: This study was conducted to investigate the comparative effects of aqueous leaves extracts of some medicinal plants; Vernonia amygdalina, Momordica charantia, Moringa oleifera, Jatropha curcas, Phyllantus amarus, and Rauvolfia vomitoria on sex hormone in male Wistar rats.

Materials and Methods: Sixty-five (65) adult male Wistar rats divided into 3 groups: control - 5 rats fed with pellet, test - 30 rats (5/leaf) and recovery - 30 rats (5/leaf) both received 0.3 ml of aqueous leaves extract of the medicinal for 21 days and the recovery group were allowed to recover for another 21 days without extract administration.

Results: The FSH levels of the various medicinal plants with the exception of Phyllantus amarus decreased significantly (p<0.05) and that of Phyllantus amarus increased significantly (p<0.05) when compared to the control group. The LH levels of the various medicinal plants decreased but not significantly (p>0.05) when compared to the control group while the testosterone levels of Momordica charantia, increased significantly (p<0.05) while that of Moringa oleifera decreased significantly (p<0.05) but others decreased but not significantly when compared to the control group. The testosterone level of Jatropha curcas increased but not significantly.

Conclusion: The current study showed that there was a decrease in the blood level of FSH in all the medicinal plants, also there were decrease in the levels of serum testosterone and LH in most of the medicinal plants which indicated negative impact hence, most of these medicinal plants should be used with caution since the usage might lead to infertility.

Published
2023-03-30
How to Cite
Osonuga, I., Olukade, B., Ogunlade, A., Edema, V., Osonuga, O., Okebule, B., & Okwute, P. (2023). THE EFFECTS OF SOME MEDICINAL PLANTS (FOUND IN SOUTHWEST NIGERIA) ON SEX HORMONES IN MALE WISTAR RATS. Asian Journal of Allied Health Sciences (AJAHS), 8(1), 15-20. https://doi.org/10.52229/ajahs.v8i1.2391
Issue
Vol 8 No 1 (2023): Vol 8, Issue 1 (Jan-Mar)
Section
Original Article
Copyright (c) 2023 Asian Journal of Allied Health Sciences (AJAHS)

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