Impact of Hypothyroidism and Lipid Profile on Obesity

Abstract

Background: Obesity is frequently characterized as a state of irregular or over the top fat collection in adipose tissue, to the degree that health might be impeded. Obesity and hypothyroidism are two common medical conditions which have been linked together closely. The clinical cardiovascular manifestation in obesity is correlated with the changing of serum lipid profile. The abnormality of fat and lipoprotein in obese patient generally are the increase of LDL, cholesterol, hypertriglyceridemia, and decrease of HDL cholesterol.

Objective: The current study aims to determine association of obesity with hypothyroidism, lipid profile and thyroid hormones.

Methodology: Total of 150 samples was collected from obese participants of > 30 BMI. For thyroid profile samples were run on (cobas e411) principle of the Electrogenerated chemiluminescence (ECL) and lipid profile on COBAS c311 on the principle of photometric assays and ion-selective electrode measurements and uses serum/ plasma.

Results: Among study participant 104 (69.3%) were females and 46 (30.7%) were males. The higher prevalence of obesity in female is the indicative risk. Result of chi square test predict; obesity and hypothyroidism P value 0.817, obesity and triglyceride 0.144, obesity and HDL 0.565, obesity and cholesterol 0.204 and obesity and LDL 0.004.

Conclusion: Crystal significant association between obesity and LDL was founded (P-value ≥0.005). No association was observed for other study variables.

Keywords: Obesity; Hypothyroidism; TSH; LDL; HDL; TG; Cholesterol