Therapeutic role of Supernatural green tea powerful antioxidant, epigallocatechin gallate effects on skin carcinomas

Abstract

Catechins, (-)epigallocatechin gallate (EGCG) present in green tea used as antioxidants containing many health benefits such as skin cancer prevention in humans. There non-toxic natural agent properties may be helpful in the management of cell proliferation or treatment of human malignancies. EGCG prevents carcinogenesis by different signaling pathways. Reactive oxygen species has the ability to damage genomic DNA resulting in mutations, proto oncogene activation and tumor suppressor gene inactivation. EGCG reduced the amount of auto phosphorylation of EGF-R caused by EGF thus plays a therapeutic role in treatment.